Research Briefing Published: 01 September 2025 Nature Biotechnology (2025)Cite this article Subjects Precision CRISPR–Cas9-mediated genome engineering remains challenging, particularly gene integration and editing in non-dividing cells. We present Pythia, a deep learning solution that forecasts optimal repair templates and enables predictable and accurate genome editing in diverse cellular contexts, both in vivo and in vitro....
Category: Art
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G-quadruplex stabilization induces DNA breaks in pericentromeric repetitive DNA sequences in B lymphocytes
Proceedings of the National Academy of Sciences, Volume 122, Issue 34, August 2025. SignificanceG-quadruplexes are guanine-rich DNA secondary structures, abundantly found in most eukaryotic genomes. Stabilization of G-quadruplexes creates an obstacle for DNA replication, particularly in DNA repair-deficient cells. We show that G…Read whole article here
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Secondary organic aerosol in urban China: A distinct chemical regime for air pollution studies | Science
In the past decades, China has witnessed high air pollution associated with rapid economic development, although regulatory efforts have alleviated the situation since 2013. Haze events characterized by high particulate matter (PM) levels in China are …Read whole article here
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The Female Artist Who Showed How Plants and Insects Relate
The full Nautilus archive • eBooks & Special Editions • Ad-free reading The full Nautilus archive eBooks & Special Editions Ad-free reading From roughly the 15th through the 19th centuries, most European botanical collectors and artists experienced the Americas through seeds and specimens painstakingly brought back from scientific voyages. But some traveled to encounter plants...
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Where no gourd has gone before | Space photo of the day for Aug. 28, 2025
The Enterprise, a ship from ‘Star Trek’ is created entirely of pumpkins and exhibited outside a castle in Germany. (Image credit: THOMAS KIENZLE/Getty Images) Every autumn, Ludwigsburg Castle in Germany transforms its grounds to host the world’s largest pumpkin exhibition. Every year brings its own theme. For 2025, the focus was “Big Movies,” which invited...
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Europe regains contact with JUICE Jupiter probe ahead of crucial Aug. 31 Venus flyby
Artist’s illustration of Europe’s JUICE Jupiter probe flying past Venus. (Image credit: ESA) Europe’s most advanced interplanetary space probe lost contact with Earth for nearly a full day leading up to a crucial flyby of Venus that will occur on Sunday (Aug. 31). The European Space Agency’s (ESA) JUICE spacecraft launched atop an Ariane 5...
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World’s most powerful solar telescope sees incredible coronal loops on the sun (image)
The smallest magnetic loops ever seen in the sun’s corona — imaged for the first time by the National Science Foundation’s Daniel F. Inouye Solar Telescope — could be the bottom floor of the machinery that powers the ferocious flares that routinely blast out from our star. “It’s a landmark moment in solar science,” said...
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NASA’s Psyche asteroid probe beams home haunting view of distant Earth (photo)
NASA’s Psyche asteroid probe captured images of Earth and our moon from about 180 million miles (290 kilometers) away in July 2025, as it calibrated its imager instrument. When choosing targets for the imager testing, scientists look for bodies that shine with reflected sunlight, just as the asteroid Psyche does. (Image credit: NASA/JPL-Caltech/ASU) NASA’s Psyche...
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Why irregular sleep puts heart failure patients in danger
People recovering from heart failure should consider improving the regularity of their sleep, a study led by Oregon Health & Science University suggests. The research team found that even moderately irregular sleep doubles the risk of having another clinical event within six months, according to a study published on August 21 in the journal JACC Advances....
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115-Million-Year-Old Dinosaur Footprints Unearthed by Recent Floodwaters
Volunteers clearing the aftermath of historic floods in Texas found something completely unexpected amid the mud and debris: dinosaur tracks from an ancient era. Paleontologists say that the huge tracks, 15 in total, are likely to have belonged to a large predator that lived 115 million years ago. An Ancient Predator Revealed Travis County in...