G-quadruplex stabilization induces DNA breaks in pericentromeric repetitive DNA sequences in B lymphocytes

Proceedings of the National Academy of Sciences, Volume 122, Issue 34, August 2025.
SignificanceG-quadruplexes are guanine-rich DNA secondary structures, abundantly found in most eukaryotic genomes. Stabilization of G-quadruplexes creates an obstacle for DNA replication, particularly in DNA repair-deficient cells. We show that G…
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