Data availabilityIllumina Sequencing data have been submitted to the Sequence Read Archive; these datasets are available under BioProject Accession no. PRJNA918691 (ref. 37). The authors declare that all other data supporting the findings of this study are available within the paper and its Supplementary Information files or on reasonable request. Plasmids are available from Addgene....
Author: artivio.eu
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CRISPR editing in the lung with novel lipids
CRISPR RNA is delivered to the mouse lung by inhalation using improved lipid nanoparticles. Many patients with inherited lung diseases lack effective treatment and could derive immense benefit from gene-editing therapies that correct the causative mutation. Direct delivery of such therapies to the lung by inhalation would be transformative, but the respiratory route of administration...
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Lipid nanoparticle-enabled gene editing in the lung via inhalation
Research Briefing Published: 30 March 2023 Nature Biotechnology (2023)Cite this article Subjects The ability to create in vivo genomic medicines for tissues other than the liver has been impeded by difficulties in delivery. Using a high-throughput platform, we developed lipid nanoparticles that can effectively deliver mRNA and CRISPR–Cas9 gene editing tools to the lungs through...
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Want to go watch the WWDC keynote at Apple Park? Here’s how to apply
Skip to content Image: Apple Attention developers! Apple is now accepting requests to attend a special in-person event on June 5 to kick off the 2023 Worldwide Developers Conference. Attendance to the event is by invitation-only at the Apple Park headquarters in Cupertino. How to get WWDC tickets? If you want to be in with...
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Rivian’s Best Accessories Removed From Online Store, for Now
News @xguntherc Mar 30, 2023, 11:25 am EDT | 1 min read Tyler Hayes / Review Geek Three of the most highly anticipated Rivian R1T accessories have been removed from Rivian’s online gear shop. Those are the awesome-looking Camp Kitchen, Gear Tunnel Shuttle, and roof-top tent. The Gear Tunnel (pictured above) is one of our favorite...
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AMC Streams More Free Shows and Movies to VIZIO Smart TVs
News @jdannychadwick Mar 30, 2023, 11:16 am EST | 1 min read VIZIO, AMC If you own a VIZIO smart TV, expect some new free streaming content to arrive on your home screen soon. This week, the VIZO and AMC Networks announced an expansion of their partnership, including nine free streaming channels and over 150...
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Samsung Galaxy S23 Owners Get a Big Camera Update
News Bug fixes, improvements, and new Gallery behavior. @andrew_andrew__ Mar 30, 2023, 11:05 am EST | 1 min read Justin Duino / Review Geek Citing user feedback, Samsung is updating the cameras in Galaxy S23 series devices. The firmware update (S91xNKSU1AWC8), which is rather large at 922.88MB, is already rolling out in South Korea. It features...
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What Is USB-C? Here’s Why You Want USB Type-C
Justin Duino / How-To Geek USB-C is a reversible connector that can be used to transmit data, video and audio signals, and PCI-E signals, among others. It also supports much faster charging speeds than USB-A — up to a few hundred watts — with USB Power Delivery. USB-C is the emerging standard for charging and...
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The Tiny ASUS Chromebox 5 Is Now up for Pre-Order
The ASUS Chromebox 5 was revealed earlier this year as a new compact desktop PC running Google ChromeOS. ASUS has now re-announced it as pre-orders become available. The ASUS Chromebox 5 was initially shown off at CES 2023, but it didn’t get a ton of attention at the time, given everything else that was going...
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States’ responses to mass shootings: Party determines policy
Public outrage is swift following mass shootings, such as the killing of six people at a Christian elementary school in Nashville, Tennessee. Sorrow and sympathy are widespread. But what comes next from policymakers is likely to depend on which political party is in charge of a state. Don’t expect new gun controls in Republican-led states,...