Joe Fedewa / How-To Geek Google Bard was released to public testing in early March, but it’s not quite as impressive as its rivals Bing Chat and ChatGPT (which were already far from perfect). Google is promising that upgrades are on the way. The latest episode of The New York Times‘ podcast Hard Fork had...
Category: Art
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The 10 Best Action Movies on HBO Max in 2023
Jason Fitzpatrick / How-To Geek With access to the Warner Media library, HBO Max features some of the biggest action movies around, from classics to recent blockbusters. Here are 10 good action movies to stream on HBO Max. Update, 3/27/23: After reviewing our guide and verifying our links are working, we’re still confident these action-packed...
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The Best Password Managers of 2023
Hannah Stryker / How-To Geek Update, 03/23/2023: We’ve reviewed our recommendations and are confident these are still the best password managers you can buy. What to Look For in a Password Manager in 2023 A password manager might seem relatively straightforward, but there’s a variety of different features that differentiate a good one from an...
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A new way to assess the propensity of rivers to generate extreme floods
Magnitude of the flood divide as a function of its physioclimatic controls. a,b, Normalized magnitude (that is, divided by the long-term mean river discharge q¯) of the flood divide in the study dataset as a function of the hydrograph recession exponent (a) and the coefficient of variation of daily flows (b). Shaded areas span the...
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Protect newborn screening programs | Science
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Combinatorial design of nanoparticles for pulmonary mRNA delivery and genome editing
Data availabilityIllumina Sequencing data have been submitted to the Sequence Read Archive; these datasets are available under BioProject Accession no. PRJNA918691 (ref. 37). The authors declare that all other data supporting the findings of this study are available within the paper and its Supplementary Information files or on reasonable request. Plasmids are available from Addgene....
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CRISPR editing in the lung with novel lipids
CRISPR RNA is delivered to the mouse lung by inhalation using improved lipid nanoparticles. Many patients with inherited lung diseases lack effective treatment and could derive immense benefit from gene-editing therapies that correct the causative mutation. Direct delivery of such therapies to the lung by inhalation would be transformative, but the respiratory route of administration...
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Lipid nanoparticle-enabled gene editing in the lung via inhalation
Research Briefing Published: 30 March 2023 Nature Biotechnology (2023)Cite this article Subjects The ability to create in vivo genomic medicines for tissues other than the liver has been impeded by difficulties in delivery. Using a high-throughput platform, we developed lipid nanoparticles that can effectively deliver mRNA and CRISPR–Cas9 gene editing tools to the lungs through...
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Rivian’s Best Accessories Removed From Online Store, for Now
News @xguntherc Mar 30, 2023, 11:25 am EDT | 1 min read Tyler Hayes / Review Geek Three of the most highly anticipated Rivian R1T accessories have been removed from Rivian’s online gear shop. Those are the awesome-looking Camp Kitchen, Gear Tunnel Shuttle, and roof-top tent. The Gear Tunnel (pictured above) is one of our favorite...
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AMC Streams More Free Shows and Movies to VIZIO Smart TVs
News @jdannychadwick Mar 30, 2023, 11:16 am EST | 1 min read VIZIO, AMC If you own a VIZIO smart TV, expect some new free streaming content to arrive on your home screen soon. This week, the VIZO and AMC Networks announced an expansion of their partnership, including nine free streaming channels and over 150...