As March was drawing to a close, a powerful solar flare exploded from the Sun, causing X-rays and ultraviolet radiation to rocket toward Earth. Peaking at 10:33 p.m. Eastern Time on March 28, 2023, the flare was of the strongest kind — an X-class flare, according to NOAA’s Space Weather Prediction Center. Traveling at the...
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How to Permanently Change Your MAC Address on Linux
fatmawati achmad zaenuri/Shutterstock You can set a permanent new MAC address in the terminal using the macchanger utility and a systemctl unit file. Or in GNOME, go to Settings> Wi-Fi [or Network]> Identity, and enter a custom MAC address. Every network interface has a unique MAC address, set by the manufacturer. It’s how network connections...
Google Bard AI Is Getting a Much-Needed Upgrade
Joe Fedewa / How-To Geek Google Bard was released to public testing in early March, but it’s not quite as impressive as its rivals Bing Chat and ChatGPT (which were already far from perfect). Google is promising that upgrades are on the way. The latest episode of The New York Times‘ podcast Hard Fork had...
The 10 Best Action Movies on HBO Max in 2023
Jason Fitzpatrick / How-To Geek With access to the Warner Media library, HBO Max features some of the biggest action movies around, from classics to recent blockbusters. Here are 10 good action movies to stream on HBO Max. Update, 3/27/23: After reviewing our guide and verifying our links are working, we’re still confident these action-packed...
The Best Password Managers of 2023
Hannah Stryker / How-To Geek Update, 03/23/2023: We’ve reviewed our recommendations and are confident these are still the best password managers you can buy. What to Look For in a Password Manager in 2023 A password manager might seem relatively straightforward, but there’s a variety of different features that differentiate a good one from an...
A new way to assess the propensity of rivers to generate extreme floods
Magnitude of the flood divide as a function of its physioclimatic controls. a,b, Normalized magnitude (that is, divided by the long-term mean river discharge q¯) of the flood divide in the study dataset as a function of the hydrograph recession exponent (a) and the coefficient of variation of daily flows (b). Shaded areas span the...
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Combinatorial design of nanoparticles for pulmonary mRNA delivery and genome editing
Data availabilityIllumina Sequencing data have been submitted to the Sequence Read Archive; these datasets are available under BioProject Accession no. PRJNA918691 (ref. 37). The authors declare that all other data supporting the findings of this study are available within the paper and its Supplementary Information files or on reasonable request. Plasmids are available from Addgene....
CRISPR editing in the lung with novel lipids
CRISPR RNA is delivered to the mouse lung by inhalation using improved lipid nanoparticles. Many patients with inherited lung diseases lack effective treatment and could derive immense benefit from gene-editing therapies that correct the causative mutation. Direct delivery of such therapies to the lung by inhalation would be transformative, but the respiratory route of administration...
Lipid nanoparticle-enabled gene editing in the lung via inhalation
Research Briefing Published: 30 March 2023 Nature Biotechnology (2023)Cite this article Subjects The ability to create in vivo genomic medicines for tissues other than the liver has been impeded by difficulties in delivery. Using a high-throughput platform, we developed lipid nanoparticles that can effectively deliver mRNA and CRISPR–Cas9 gene editing tools to the lungs through...










