Home Art DNA methylation shapes transcription factor binding beyond canonical CpG contexts

DNA methylation shapes transcription factor binding beyond canonical CpG contexts

Proceedings of the National Academy of Sciences, Volume 122, Issue 51, December 2025.
SignificanceAlthough DNA methylation has long been recognized as an epigenetic regulator, the functional impact of methylation beyond CpG sites—particularly non-CpG and hemimethylation—remains poorly understood. Using a high-throughput, cell-free binding …
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DNA methylation shapes transcription factor binding beyond canonical CpG contexts

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